Permission Denied error in Sage Intelligence

We are seeing that every icon in Sage Intelligence is returning a permission denied error. This is happening for all users, including the admin user. It happens both when Sage 300 is run as administrator and not. Sage 300 v2022 PU 4. It was working fine last week, no updates have been applied or changed since last week. This includes no Windows or Office updates. I can see there are reports on this issue from many years ago, but they all suggest a resolution found in an old KB from SageIntelligence.com which no longer works. Anybody got a suggestion? 

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