Yes, general ledger entries are treated the same as A/P module entries.  The reconciliation amounts are the G/L amounts, so it doesn't matter whether the cards are posted through A/P or through the G/L.  

If you set up the credit card G/L account for reconciliation, it will reconcile like any bank account.

So yes, if you've sorted out what should, and should not be there, you can combine the corrections into one summary entry.

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For Credit Cards, I've found that only, always, exclusively entering everything through the Purchase / A/P module in SA works out better.   There's almost always an invoice, most slips have at least a unique 'transaction I.D'.  

For transactions that just plain do not have an invoice number, I use a consistent date format (i.e. 2015-11-21) as the invoice number, to help avoid duplicates.

I don't know when or why (perhaps from course work that's intentionally difficult), it seems that  some book-keepers have gotten the idea that it's best to use the G/L first, and the other Sage 50 screens are only a last resort, or for noobs that don't grok the debits and credits.  

I'm of the opposite opinion.