Could be related to Windows Defender.

Either Windows Defender Smartscreen, Real Time Protection, or Reputation-Based Protection.

You can set an exclusion rather than turning off protection: 

https://support.microsoft.com/en-us/windows/add-an-exclusion-to-windows-security-811816c0-4dfd-af4a-47e4-c301afe13b26

Hi DGR,

Thanks for the reply. Our Microsoft defender is turned off, and i could not find the manage settings Exclusion section either.

Just to clarify: this is not the message you are getting?

 .  

Hi DGR, 

I apologize, i should of been more clear, we get the pop up window and when we click on "More Info" the App name is "Launcher32.exe" and not "setup.exe"

Hi DGR, 

I apologize, i should of been more clear, we get the pop up window and when we click on "More Info" the App name is "Launcher32.exe" and not "setup.exe"

the screen was just a sample one (so it said setup.exe).. if the first screen is the same, then it is Windows Defender/Windows Security - Smartscreen - that is blocking the Launcher32 application.  You can try renaming the "SAGE 100" folder under the Windows user's Documents folder and see if that is able to launch Sage 100. if message still appears (possibly referring to a different launcher program such as Launch32 or Launcher2016.exe) then you may want IT to look at disabling that SmartScreen temporarily to confirm that is issue and then find way to exclude the launcher program going forward.