We are getting a message stating that "A payroll tax update is avaialble, but it cannot proceed because a payroll run is in progress in Payroll Data Entry." There is a More Info link that lists three company codes as having pending payroll data entry.  Those companies have been checked and both the payroll data entry and check/daily transaction registers are clear/empty.  

We are on Sage 100 2021 update 2, and payroll 2.22.