Close Sage 100.  Then, try renaming the Sage100 folder in your local Documents folder.  Open Sage 100 again.

Thanks for the suggestion!  It worked when we selected Standard desktop but if we selected the Classic desktop like it was before we have the same problem with only the Information Center coming up.  We're upgrading to V2021 very soon so everyone will be on Standard desktop anyway so we're all set.  Happy New Year1

Glad it helped!  Happy new year!