Portal on Windows 2012

Has anyone managed to get this to work?  Customer gets Error 500.19 pages and I haven't been able to make it do anything else.  The related error text is "Internal Server Error - The requested page cannot be accessed because the related configuration data for the page is invalid."  Does anyone know which file this is referring to?  I'm guessing it's a permissions issue on whatever file the configuration data is in.
Sage 300 ERP 2012
Windows Server 2012
SQL Server 2012

rgds
Paul